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Search Results for " guanylate cyclase "

20

Compounds

Cat No. Product Name Synonyms Targets
T38770 Guanylate cyclase-IN-1
Guanylate cyclase-IN-1 (Example 46) is a specific inhibitor of guanylate cyclase, employed in research related to cardiovascular diseases.
T9080 Plecanatide Guanylate cyclase
Plecanatide acetate is an analogue of Uroguanylin. It is an orally active guanylate cyclase-C (GC-C) receptor agonist.
T11852 Linaclotide Guanylate cyclase
Linaclotide developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation, and is a potent and selective guanylate cyclase C agonist.
T16808 Runcaciguat Others , Guanylate cyclase
Runcaciguat is a soluble guanylate cyclase stimulator. Runcaciguat combines with selective partial adenosine A1 receptor agonists and can be used in studies about cardiovascular and renal diseases.
T21607 Ataciguat HMR-1766 Others , Guanylate cyclase
Ataciguat (HMR-1766) (HMR-1766) is a potent and specific soluble guanylate cyclase (sGC) activator.
T19777 ODQ Apoptosis , Others , Guanylate cyclase
ODQ is an effective and selective soluble guanylyl cyclase (sGC) inhibitor.
T16344 NS-2028 Others , Guanylate cyclase
NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor (IC50: 30 nM and 200 nM for basal and NO-stimulated enzyme activity). It is commonly used in the research of nitric oxide signaling pathways. NS-2028...
T6775 BAY 41-2272 Guanylate cyclase
BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.
T1984 Cinaciguat BAY 58-2667 Guanylate cyclase
Cinaciguat (BAY 58-2667) (BAY 58-2667) is the first of a new class of soluble guanylate cyclase (sGC) activators in Clinicalal development for acute decompensated heart failure.
T16569 Praliciguat IW-1973 Others , Guanylate cyclase
Praliciguat (IW-1973) stimulates sGC in HEK-293 cells (EC50: 197 nM). Praliciguat is an effective and orally active soluble guanylate cyclase stimulator. It also enhances NO signaling and acts as a vasodilator.
T16383 Olinciguat IW-1701 Guanylate cyclase
Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator. It also has concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole-cell assay.
T17226 Vericiguat BAY1021189 Guanylate cyclase
Vericiguat (BAY1021189) is a potent and orally available guanylate cyclase stimulator.
T6968 Riociguat BAY 632521 Guanylate cyclase
Riociguat (BAY 632521) is a stimulator of guanylate cyclase which causes relaxation of vascular smooth muscle and is used to treat severe pulmonary arterial hypertension.
T4381 Lificiguat YC-1 Others , Guanylate cyclase , HIF
Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).
T21712 BAY 41-8543 Others , Guanylate cyclase
BAY 41-8543 is a nitric oxide (NO)-independent stimulator of soluble guanylyl cyclase (sGC).
T12670 (Rac)-MGV354 MGV354 Others
(Rac)-MGV354 (MGV354) is the racemate of MGV354. MGV354 is a soluble activator of guanylate cyclase (sGC)(EC50s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively).
T7201 Nelociguat BAY60-4552 Guanylate cyclase
Nelociguat (BAY60-4552)(BAY60-4552) is a soluble guanylate cyclase stimulator (sGC stimulator). Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxide (NO) signalling pathway.
T6888 Methylene Blue methylthioninium chloride,CI-52015,Tetramethylthionine chloride,Basic Blue 9 Guanylate cyclase , Microtubule Associated , NO Synthase , Parasite , Monoamine Oxidase
Methylene Blue (Tetramethylthionine chloride) (IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.
T0006 Methylene Blue trihydrate Methylthionine chloride,Basic blue 9,Methylene Blue Guanylate cyclase , Microtubule Associated , NO Synthase , Parasite , Monoamine Oxidase
Methylene Blue trihydrate (Basic blue 9) is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene Blue trihydrate...
T21576 LY83583 6-Anilino-5,8-quinolinedione,6-anilinoquinoline-5,8-dione Guanylate cyclase
LY83583 is a soluble guanylate cyclase competitive inhibitor with IC50 of 2 µM.

Compounds

Guanylate cyclase-IN-1
T38770
Synonym:
Target:
Plecanatide
T9080
Synonym:
Target: Guanylate cyclase
Linaclotide
T11852
Synonym:
Target: Guanylate cyclase
Runcaciguat
T16808
Synonym:
Target: Others, Guanylate cyclase
Ataciguat
T21607
Synonym: HMR-1766
Target: Others, Guanylate cyclase
ODQ
T19777
Synonym:
Target: Apoptosis, Others, Guanylate cyclase
NS-2028
T16344
Synonym:
Target: Others, Guanylate cyclase
BAY 41-2272
T6775
Synonym:
Target: Guanylate cyclase
Cinaciguat
T1984
Synonym: BAY 58-2667
Target: Guanylate cyclase
Praliciguat
T16569
Synonym: IW-1973
Target: Others, Guanylate cyclase
Olinciguat
T16383
Synonym: IW-1701
Target: Guanylate cyclase
Vericiguat
T17226
Synonym: BAY1021189
Target: Guanylate cyclase
Riociguat
T6968
Synonym: BAY 632521
Target: Guanylate cyclase
Lificiguat
T4381
Synonym: YC-1
Target: Others, Guanylate cyclase, HIF
BAY 41-8543
T21712
Synonym:
Target: Others, Guanylate cyclase
(Rac)-MGV354
T12670
Synonym: MGV354
Target: Others
Nelociguat
T7201
Synonym: BAY60-4552
Target: Guanylate cyclase
Methylene Blue
T6888
Synonym: methylthioninium chloride,CI-52015,Tetramethylthionine chloride,Basic Blue 9
Target: Guanylate cyclase, Microtubule Associated, NO Synthase, Parasite, Monoamine Oxidase
Methylene Blue trihydrate
T0006
Synonym: Methylthionine chloride,Basic blue 9,Methylene Blue
Target: Guanylate cyclase, Microtubule Associated, NO Synthase, Parasite, Monoamine Oxidase
LY83583
T21576
Synonym: 6-Anilino-5,8-quinolinedione,6-anilinoquinoline-5,8-dione
Target: Guanylate cyclase
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TargetMol